Comt overmethylation. Bad mistake. Slowly trying this again. Mar 10, 2021 · Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases. If the box above says “upgrade to paid,” you need to upgrade to receive the protocol. Histamine is a major brain neurotransmitter, but is known popularly for its role in allergic symptoms. I'll bet you exhibit some of symptoms of undermethylation too. Then I started into psychosis. The PEMT enzyme is commonly slowed down by polymorphisms, making it unresponsive to estrogen levels. It can definitely lower serotonin levels in the brain. SNPS on these genes can all cause treatment conflicts and problems tolerating increases in methylation and the associated increases in neurotransmitters, ATP and thyroid hormones. It is hydroxocobalamin that’s effective in speeding up your COMT, resulting in less dopamine, norepinephrine, epinephrine, oestrogen etc. Mar 10, 2021 · If it is overmethylation, my suggestion is to try some hydroxocobalamin (b12) which will soak up methyl groups and calm you down. Magnesium is another important supplement for people with a slow COMT. Jul 5, 2018 · Here are some of those precursors and cofactors you should add to your diet to help with your undermethylation: Choline – An important methyl donor. Scientists tell us that the number of different genetic combinations possible in a child from the same two parents exceeds 42 million. Apr 29, 2017 · Vitamins C 500-1000 mg twice a day. "Normally I take niacinamide to calm this feeling down and it works. Jun 25, 2018 · Schizophrenia. Sep 13, 2016 · 10 months - Hydroxy B12 4000mg/day (MTHFR Support) (taking hydroxyl version due to COMT and intolerance of Methyl b12) 3 weeks - Methyl B12 65mg. Enter your email, click “subscribe,” and select a paid option to get my MTHFR Protocol: Subscribe. So, the bottom line is to look for a pattern of elevated catecholamines and low metanephrines, as that usually reflects slow COMT activity. Extreme juice cleanses, detox programs, and restrictive Slow COMT cause overmethylation? Is slow COMT mutations cannot take methylgroups without causing overmethylation and anxiety does that mean that we overmethylate by default? COMT and supplement interactions | Genetic Lifehacks. One gene methyl turns off is the serotonin reuptake gene. The Methylation Cycle is a biochemical pathway that manages or contributes to a wide range of crucial bodily functions, including: Detoxification. No scientific data; just the ass-pull claims of some quacks. Many of the symptoms of overmethylation can be tied to another diagnosis. Chronic stress & trauma Jul 26, 2020 · When supplementing with methylated supplements (e. Question. There is. They may play a major role in your reaction issues. 4. 01:13:15 - Schizophrenia is a name given to several completely different diseases. MTHFR genetic mutations affect methylation. This is because overmethylation can create high levels of dopamine, norepinephrine, and epinephrine in the brain. Detox. Energy production. Michael Veselak at (805) 482-0723. We found the B12 can cause more issues than anything else. Histapenia – Over methylation. Aug 11, 2004 · The literature on phenotypic associations of the COMT Val158Met polymorphism is reviewed, highlighting areas where this hypothesis may have explanatory value, and pointing to possible directions Nov 24, 2023 · A person should contact a doctor if they experience any symptoms of a folate or vitamin B12 deficiency, which may include: fatigue. A reaction to methylated products can be for several reasons, the most common being: Further genetic mutations that impact the passage or metabolism of methyl products in the body, thereby leading to a ‘block’ and build up of methyls. Hopefully as you address MTHFR, especially with the added choline, your ALT will come down (mine did). this is from a multivitamin, seeking health Summary: Anyone who says solid science OR quackery has not considered the whole picture. Apr 4, 2023 · ccess it from the bottom of each email or from the ebooks menu. Composed of three amino acids - cysteine, glycine, and glutamic acid - glutathione can be found in every cell of the human body. They sit back and take it easy about things. This single carbon metabolic process is mediated by enzymes such as methyltetrahydrofolate reductase (MTHFR), catechol-O-methyltransferase (COMT), and cystathione beta May 20, 2021 · Methylation is crucial to happiness and well-being. It is also involved in the metabolic process of various hormones and drugs incorporating catecholic structures. MTHFR is an enzyme and the MTHFR gene is necessary for the creation of the enzyme which regulates the methyl cycle. As a fast COMT Val/Val, I find L-theanine (from green tea) seems to help. 1 Biochemical Individuality and Nutrition. Dr. Magnesium – Plays an important role and gene methylation. Jan 1, 2024 · Catechol- O -methyltransferase (COMT) is a magnesium-dependent enzyme responsible for the catalytic O -methylation reaction of endogenous catecholamines and neurotransmitters. Is slow COMT mutations cannot take methylgroups without causing overmethylation and anxiety does that mean that we overmethylate by default? Should I take things like niacin in this case? 1. as I am avoiding taking more due to overmethylation in the past. When these stress hormones rise inside the body, people with COMT and MAO SNPs will experience side effects of these powerful hormones. Jun 3, 2016 · I'm fairly confused. Hydroxocobalamin can also act as a scavenger of Abstract. COMT: One theory is that Lithium may increase or support the COMT enzyme that helps degrade the neurotransmitters raised during "overmethylation" (5) Well, methyl b12 and methyl folate are used for under methylation, so if you think you're "overmethylated" you might want to avoid the methylated forms of these vitamins. Correct your nutrition and supplement for under-methylation. The best clinic management software. See your doctor and talk to them about what you’re experiencing. Hard part on giving advice here is the antidepressants. Overmethylation Many persons who suffer from anxiety and depression are over-methylated which results in excessive activity at dopamine, norepinephrine and serotonin receptors. Manganese 10 mg once a day. Although its classical function has been In theory, you could raise your homocysteine or histamine levels to the point of psychosis. In both sexes, COMT-dependent pain responses reach a plateau when stress reaches a certain level, although the plateau occurs at lower levels of stress in females compared to males. Sep 27, 2014 · Overmethylation & Depression Biotypes: 2 nd of 5 Subsets. Folate or folic acid appears to turn this gene on. . Wondering whether quercetin would be even more effective. Histapenia is a shortage of histamine in the body. Impaired methylation can lead to mental health issues. Sep 27, 2021 · COMT activity decreases four times if the Met allele is homozygous [8,9]. The catechol-O-methyltransferase (COMT) gene is of significant interest to neuroscience, due to its role in modulating dopamine function. Jan 8, 2020 · The COMT gene controls the breakdown of neurotransmitters such as dopamine. The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. 1 mg B12 as a starting dose is pretty high. I started getting very dizzy for a few days when I would take methylB12 and methylfolate and I had been taking them both for a little over a month. The Val (108/158) Met polymorphism modulates COMT activity and thus dopamine levels, and has SAM is the main methylation output. O -Methylation by catechol- O -methyltransferase (COMT) blocks their estrogenicity and prevents their oxidation to quinones. For the above combination to work you also need adequate levels of essential fatty acids at 1 to 2 teaspoons of quality fish oil per day. 394K subscribers in the Nootropics community. The highest concentrations of glutathione are found in the skin and liver, making it critical in the body's detoxification process. glycine has been a miracle for me. Apologies if I'm using stereotypes, but the Chinese population seem to have higher rates of this genetic polymorphism and drink a fair amount of green tea. As you improve methylation with the MTHFR protocol, your COMT performance should improve notably. A single gene encodes both membrane bound (MB) and soluble (S) forms of COMT. In many cases the underlying molecular basis for these effects is unknown Try doing it with Folate in the form of methylfolate, maybe you have folic acid conversion issues and methyl folate might be a better suit for you. , PLS1 SNP profile) modulates the 3 raw MRI measures of the rFFA, we correlated the PLS1 COMT scores with FS, GMV Feb 15, 2017 · However—as with many things in functional medicine—genes don’t tell the full story. Shop the outside of the supermarket, avoiding the isles. I previously took methyl folate for months. Apr 1, 2002 · OBJECTIVE: In the prefrontal cortex, the enzyme catechol O-methyltransferase (COMT) is critical in the metabolic degradation of dopamine, a neurotransmitter hypothesized to influence human cognitive function. I prefer niacin as well. Not flooding the methyl donor pathway with jujst B12. - End test: 5k IU of vitamin D (this consistently produces “overmethylation” symptoms for me) Results : The initial doses of lithium orotate generated “overmethylation” side effects. Inadequate intake of any of these nutrients can impair methylation. . So if it works for you, it's probably best to go with it. You can effectively be simultaneously over- and under- methylating. 74% of women have at least one copy of a slowed PEMT. Substance use often starts in adolescence and poses a major problem for society and individual health. That's all I know that's relevant to your question, but There are tons of things that can cause social anxiety. One way MTHFR can contribute to overmethylation is due to reduced toxin clearance from undermethylation. Glutathione (GSH) is often referred to as the body's master antioxidant. It is a process by which methyl groups are added to a DNA molecule. Typical symptoms include chemical and food sensitivities, sleep disorders, underachievement, upper body pain, and an adverse reaction to serotonin-enhancing substances Jan 24, 2024 · 01:10:04 - Dr. It stopped the reaction, but came with its own (thankfully temporary) side effects – flushing and itching. 1. May 7, 2024 · The effect of magnesium on the COMT enzyme. Depression can be one of 5 different disorders. Genetically, this is known as the Val158Met Aug 5, 2002 · Much more of the genome is generally subject to undermethylation rather than overmethylation. I have tried 400mcg metafolin + 1mg hydrox and it makes me wired and destroys my sleep Jan 1, 2024 · Catechol- O -methyltransferase (COMT) is a magnesium-dependent enzyme responsible for the catalytic O -methylation reaction of endogenous catecholamines and neurotransmitters. Immune function. shortness of breath. COMT has become an attractive biological target in the Oct 4, 2020 · Neutral methylation makes up another 40% of the population and Overmethylation constitutes the remaining 15% of the population, solidly holding the black-sheep position in most families. So for this reason, I don’t recommend using niacin to buffer excess methyl groups. ”. Jun 3, 2016 · 457. There isn't. Currently, he researches, writes and presents worldwide on the topic of MTHFR and methylation defects. I have read @Freddd say that it isnt overmethylation and is just paradoxical folate deficiency and or potassium deficiency. After 3 years of chasing histamine, genetics, and finally realizing i was having overmethylation and LOW histamine , with histamine producing gut infection Citrobacter and proteus, which complicates it Jun 9, 2017 · Folate appears to increase acetylation of chromatin, though the mechanism is unknown. Because SAM-e and Methionine raise Homocysteine, it's important to only have the dose you need. Having methylation work efficiently is important if you want to feel good. Dec 29, 2023 · Overmethylation aka hypermethylation, occurs when there’s an excess of methylation in the body. Monoamine oxidase (MAO) converts both metanephrines to VMA. Since COMT needs SAM to function, you are likely experiencing a number of symptoms that someone with slow COMT would experience. There is no one perfect diet for everyone but as Michael Pollen said, “eat food, mostly plants, not too much. Each of us has innate biochemical factors which influence personality, behavior, mental health, immune function, allergic tendencies, etc. Methionine is easy on the gut and much less expensive. Feb 7, 2020 · To explain how this profile (linear combination) of the 12 COMT genotypes (i. I popped these suckers like candy that night. In researching this and looking closely at the biochemistry, it makes sense why some react poorly to methylfolate, methylcobalamin or folic acid. Methyl b12 can produce more neurotransmitters I believe. Niacin is a nutrient. EVALUATION & TREATMENT OF OVER- AND UNDER-METHYLATION IN THE PSYCHIATRIC POPULATION Nov 30, 2023 · COMT is also associated with greater levels of cortisol and HPA axis dysfunction (which is largely responsible for the body's ability to calm itself and de-stress ). methylfolate or methylcobalamin) there is potential to react to them. Jan 8, 2014 · Estrogen is required for the PEMT enzyme to activate and function normally. That is to say, if whole blood histamine is low, the individual will be overmethylated and if it is high, they will be undermethylated Slow COMT A few people I’ve spoken to with “overmethylation” have a slow COMT. Jan 30, 2024 · Getting sick can change your methylation levels as well, and staying healthy will definitely decrease the odds you get sick! [10] 2. this is from a multivitamin, seeking health Jun 27, 2017 · Methylation adds a methyl group to our DNA, and in doing so is responsible for many biochemical activities in the body, which effect our energy levels, immune system, mood, the way we detoxify and many more. Briefly, COMT gene-specific PCR products encompassing the polymorphic region were cleaved by the NlaIII restriction enzyme to an 88 bp fragment and two variable fragments 96 and 114 bp in length, which indicated the Met and Val alleles, respectively Dec 17, 2013 · It got bad enough that I sent Tom to buy me the form of niacin known as nicotinic acid, which soaks up the extra methyl groups floating around in the case of overmethylation. Patients with low blood histamine tend to have depressed metabolism, a pear shaped body and some may have certain psychological conditions such as anxiety and Aug 11, 2015 · OVERMETHYLATION: [Think high methyl, low folate and high neurotransmitter (serotonin, dopamine and norepinephrine) activity. COMT has become an attractive biological target in the Jun 27, 2012 · Overmethylation and Undermethylation: Case Study. His passion for identifying the cause of disease directed him towards nutrigenomics and methylation dysfunction. 2. But what is confusing to me is one time I didn’t have niacinamide and I took 800 mcg of folic acid instead. The idea here is that an increase in methyl donors creates more catecholamine neurotransmitters that the slow COMT has trouble breaking down. The third of the four biochemical subtypes is overmethylation. The current study investigated whether prefrontal cognition varies with COMT Oct 11, 2018 · You’re relying on your ownwisdom instead of the wisdom of the system, which is what you’re relying on when you use glycine as the natural, normal physiological methyl group buffer. Improving methylation will therefore increase SAM, which will improve COMT breakdown of dopamine. The COMT gene contains 34 single nucleotide polymorphisms (SNPs). Nov 1, 2006 · The COMT Val158Met polymorphism analysis was performed as described under Materials and Methods. Undermethylation due to MTHFR or related issues therefore causes lower SAM levels, which makes COMT perform even worse, and therefore tonic dopamine can be even higher. Walsh’s elevator pitch is for the government to stop killing off critical NIH research. This case study shows how fast methylation can become imbalanced – and how fast it can be rebalanced. Both were sublingual vitamins. Folic acid helped at a faster rate than Niacinamide. Under Methylation. People who are experiencing overmethylation are generally very anxious. Meaning that my body can make its own methyl folate with no problem. If the box says “subscribed,” you are a Masterpass member. Oct 18, 2016 · Benjamin Lynch, ND received his Cell and Molecular Biology, BS from the University of Washington and his ND from Bastyr University. constipation. Also, taking too much can make you feel worse. (By the way, methylfolate in this case means 5-MTHF or L-5 Mar 5, 2017 · It is his mission to leave no stone unturned in getting to the root cause of your pain, rather than merely treating the symptoms with medications. The optimal diet is essentially vegetarian, with whole foods including complex carbohydrates, vegetables and fruits and only moderate protein. This worked the same, if not quicker than A good base recommendation is 400mcg of folate per day and double that amount of B12. As for folinic: some people do much better on folinic acid than on methylfolate. I tested negative for the Motherfucker mutation. Jan 26, 2016 · 3. Supplemental nutrient efficacy can be diminished with a diet that is inappropriate for your biotype. … Neutralising a Methyl Reaction Dec 28, 2014 · As I have shown, gut byproducts that increase the levels of stress hormones – phenols, aromatic amino acids, and aldehydes – will tend to cause anxiety and many other symptoms of overmethylation. You can even take folic acid. Carl Pfeiffer in his book Nutrition and Mental Illness, An Orthomolecular Approach To Balancing Body Chemistry. It is the process by which our epigenetics regulate gene expression. It can be triggered by several factors, including: Excessive Supplement Intake: Probably the most common trigger is overuse of supplements like SAMe or methylated B vitamins, which can lead to overmethylation. I hear it a few times a week while working with clients and guiding various doctors. In mammals, DNA methylation is an essential process required for normal development and is also associated with key processes like genomic imprinting, aging carcinogenesis, etc. Balance lithium levels. A high percentage are non-competitive persons who complain of chemical and food sensitivities… – shootings at Columbine High School and Virginia Tech were carried out by students taking SSRIs. In this episode we discuss: Why methylation is so important. Feb 15, 2023 · In contrast, overmethylation may lead to excessive activity of these neurotransmitters, which can also contribute to depression. Walsh, PhD, FACN. They are also thrill seekers. Today I talk with methylation expert Dr. The valine108 (S-COMT)/158 (MB-COMT) SNP encodes a low activity form of COMT Sep 15, 2020 · Methylation Basics Methylation is the transfer of one carbon methyl group from one molecule to another that either activates or deactivates that molecule. Copper – Many methylation enzymes require copper for reactions. If you have too little reuptake, serotonin will be too high. Discussion of nootropics and cognitive enhancers. g. Work with your doctor to develop a treatment plan. e. Optional quercetin 300 mg one with each meal. a loss of appetite or Undermethylation. Jul 28, 2019 · Methylation Diet Considerations. 7/ It's important to know that cofactors are equally important. High protein diets should be avoided as most protein contains histidine, an amino acid used by the body to produce histamine. Genomic hypermethylation in cancer has been observed most often in CpG islands in gene regions. As someone with slow COMT, that is also how Both the HPS haplotype and stress lead to increased pain sensitivity that is sex-dependent, likely in an epinephrine-mediated manner. Maintaining DNA. Jul 12, 2021 · Genes that cause these types of impacts could include COMT, CBS, GAD1, MAO, DAO, etc. Dec 19, 2020 · DNA Methylation. Folinic acid uses up methyl to become the active form. Ovmethylation isn’t caused by just one thing – it’s a tendency based on your genes, lifestyle, stressors, diet, and environment. COMT and supplement interactions | Genetic Lifehacks. I used this successfully early on in my methylation protocols when methylcobalamin would cause anxiety. If anyone had any doubts, human biology doesn’t lend itself to simple compartmentalization. Specifically, I experienced (1) headaches (general cranial pressure), (2) anxiety and (3) restlessness that led to insomnia (as well as potentially (4 Hydroxocobalamin is a lesser-used bioactive form of B12 that is tolerated by many and understood to help the body promote neurotransmitters (for healthy brain function), protect against anemia (sometimes used for pernicious anemia), detoxify, manufacture myelin sheath, and much more. In many cases, high serotonin levels can cause psychological problems including reduced motivation, reduced libido, weight gain, and Aug 1, 2012 · The review closes with a discussion of the impact of additional COMT polymorphisms on brain structure and function, as well as gene-gene interactions between COMT and other learning-relevant genes. Nov 15, 2011 · People with MTHFR mutations and high homocysteine – especially those who are homozygous MTHFR – should respond favorably to methylfolate. Future studies should try to disentangle the complex effects of COMT Val158Met on brain functions by taking gender, age, ethnicity, endophenotypes Jan 1, 2019 · The influence of individual differences in cognition and behavior may be partly explained by the different genetic polymorphisms. Apr 30, 2017 · Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Ever. I am going to share with you a classic situation which happens all the time. By William J. Three genotypes of COMT - Val/Val, Val/Met, and Met/Met display high, intermediate, and low activity of the COMT enzyme, respectively. With very few exceptions, these persons report intolerance to SSRI antidepressants and antihistamines. The dopamine system plays a role in substance use, and catechol-O-methyltransferase (COMT) is an important enzyme that degrades dopamine. It's not so good for us. Most people will have symptoms and personality traits on both sides of the spectrum, but you might notice more of a trend in one direction or the other. Amy Yasko’s Approach — Dr. Kara Fitzgerald about the impact of diet and lifestyle on methylation and why supplementation can sometimes be harmful. Do you know if you have any genetic mutations on the MTHFR or COMT genes? Both influence methylation and both can lead to anxiety and insomnia if not managed properly. I generally recommend supplementing with magnesium at a minimum of around 400 mg per day. 3. Glutathione – Low glutathione levels can impair methylation. Overmethylation. Like SAMe, magnesium is also a cofactor for the COMT enzyme—it also attaches to COMT to help it function properly. Why SNPs don’t tell the whole story. Nov 4, 2014 · Four Ways to Manage Your MAO and COMT Genes: 1) Calm down gut inflammation by avoiding food allergens and processed, garbage GMO foods. Niacin is much safer for me. adenosylcobalamin is neutral. Nov 22, 2017 · Histamine and methyl are inversely related to one another. glycine makes me feel horrible, it depletes methionine. if there is such a thing as over-methylation. If you or someone you know is suffering from a chronic condition, please contact Dr. Overmethylation plays an important role in the presentation of ADD symptoms. Nov 28, 2023 · Part 2: Understanding Undermethylation and Overmethylation. The Walsh Approach seeks to identify these imbalances through various laboratory tests, specifically and assess the individual's specific needs for targeted nutrient therapies to help restore balance to the Sep 13, 2016 · 10 months - Hydroxy B12 4000mg/day (MTHFR Support) (taking hydroxyl version due to COMT and intolerance of Methyl b12) 3 weeks - Methyl B12 65mg. Hopefully we will be able to provide / find information that will help. Among the genetic polymorphisms capable of altering cognitive and behavioral functions, the catechol-O-methyltransferase (COMT) Val158Met polymorphism regulates the availability of dopamine (DA) in the prefrontal cortex and has a trimodal distribution in the Feb 28, 2006 · The enzyme catechol- O -methyl transferase (COMT), identified in the 1950s, 1 is involved in catabolism of monoamines that are influenced by psychotropic medications, including neuroleptics and Riboflavin fixed my over methylation. Even if you have the MTHFR heterozygous, you should supplement with normal daily dose of 400mcg. Do you think you have a methylation disorder? Learn the symptoms of poor methylation. In your case fast COMT is also contributing to your overmethylation symptoms. 01:13:14 - The number one reason that people decline mentally is from a zinc deficiency. You should get the amount of niacin that you need to Overmethylation (Histapenia): Too much methyl (a carbon group with three hydrogen atoms). People with too many methyl groups, also called overmethylators, tend to be more laid back. Sep 1, 2014 · COMT is the enzyme that methylates norepinephrine to normetanephrine, and epinephrine to metanephrine. Balance supplements, including a multi and B complex. We started much, much lower. Mood balancing -neurotransmitters such as serotonin, dopamine and melatonin are made by the methylation process. Yasko’s supplement protocol is a six-step process. But it may good starting point for the individual. ” This causes an overproduction of serotonin, norepinephrine, and dopamine in the brain. Doesn’t explain depressive symptoms though. Methylation, a fundamental biochemical process in the body, plays a crucial role in maintaining health and well-being. For example, undermethylated individuals on plant-based, high folate diets will not be able to repair methylation status without adequate protein intake. This can change the activity of DNA without changing the sequence of the molecule. Check your genetic raw data to see if you carry the COMT variants. However, imbalances in methylation can lead to two distinct conditions: undermethylation or overmethylation. In general, your neurotransmitter activity is strongly associated with your ability to appropriately use methyl groups. It’s not as simple as “over or under” when discussing methylation cycles. If you have too much serotonin reuptake happening, serotonin levels will be low. Jun 21, 2017 · The two most important nutrients in methylation pathways are B12 and folate, but other nutrients such as methionine, cysteine, taurine, DHA, zinc, magnesium, potassium, riboflavin, niacin, pyridoxine, betaine, choline, and sulfur also play a role ( 10 ). There are several other functional COMT genotype polymorphisms present that are associated with neuropsychiatric disorders. COMT is dynamically regulated; its expression is altered during normal brain development and in response to environmental stimuli. Men and postmenopausal women have an elevated risk of choline deficiency due to low estrogen levels. Some people start with SAM-e and transition to Methionine. If you possess a polymorphism of the MTHFR gene, this may be directly associated with poor methylation (undermethylation) or highly efficient methylation (overmethylation). It is very active in the brain, and too much leads to “too much of a good thing. To start, 1) tinnitus is an identified symptoms of overmethylation [1,2] and, while I couldn’t find information on it, it is possible that sound sensitivity could also be related as it is similar to other noted side effects (headaches, irritability, exhaustion). And also that folinic acid causes blockage of methylfolate. Niacinamide and Folic Acid (800mcg) help overmethylation symptoms. ] Symptoms and Traits: High artistic or musical ability ; Hyperactivity, high energy, verbose (likely due to high neurotransmitter activity) High empathy for others, good neighbor, noncompetitive in sports Feb 7, 2021 · Overmethylation, as we have discussed, is the least common state according to the research of Dr. Methylation plays an important role in regulating key neurotransmitters essential for mental health. mi ox jc nm ob yo mj up zz he